Uveal Melanoma: Molecular Pattern, Clinical Features, and Radiation Response
نویسندگان
چکیده
منابع مشابه
Translating uveal melanoma cytogenetics into clinical care.
OBJECTIVE To report our experience in translating uveal melanoma cytogenetics to routine clinical practice. METHODS In 1998, we confirmed that monosomy 3 in uveal melanomas correlates with mortality. In 1999, we started offering all patients treated by enucleation or local resection the possibility of monosomy 3 testing, using fluorescence in situ hybridization. In 2006, we started analyzing ...
متن کاملPhotoacoustic imaging features of intraocular tumors: Retinoblastoma and uveal melanoma
The purpose of this study is to examine the capability of photoacoustic (PA) imaging (PAI) in assessing the unique molecular and architectural features in ocular tumors. A real-time PA and ultrasonography (US) parallel imaging system based on a research US platform was developed to examine retinoblastoma in mice in vivo and human retinoblastoma and uveal melanoma ex vivo. PA signals were genera...
متن کاملOptic nerve invasion of uveal melanoma: clinical characteristics and metastatic pattern.
PURPOSE To determine the frequency of optic nerve invasion in uveal melanoma, to identify clinical factors associated with optic nerve invasion, and to analyze the metastatic pattern and the association with survival. METHODS All iris, ciliary body, and choroidal melanomas (N = 2758) examined between 1942 and 2001 at the Eye Pathology Institute, University of Copenhagen, Denmark, and the Inst...
متن کاملUveal Melanoma
The eye’s uveal tract consists of the iris, ciliary body, and choroid. It contains a population of melanocytes. Uveal melanomas develop from melanocytes that reside within the stroma of the choroid, ciliary body or iris. The choroid is the vascular part of the human eye between retina and sclera. Though accurate measurements of the choroidal blood flow is difficult, it is known that choroid is ...
متن کاملUveal Melanoma.
BACKGROUND: Malignant melanoma of the uveal tract is a rare malignancy but a significant cause of mortality and visual loss. Approximately 50% of patients diagnosed with a melanoma of the choroid or ciliary body will die of the disease within 15 years of enucleation. METHODS: The author reviewed the current literature on the clinical findings, epidemiology, and treatment of uveal melanoma. RESU...
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ژورنال
عنوان ژورنال: American Journal of Ophthalmology
سال: 2012
ISSN: 0002-9394
DOI: 10.1016/j.ajo.2012.02.022